A 30-year-old female patient with a known history of SLE, characterized with positive anti-Smith, chromatin, ribonucleoprotein (RNP), Sjogren’s syndrome-related antigen A (SSA), and scleroderma (Scl-70) antibodies, presented to the emergency department with a two-day history of severe bilateral knee arthralgia (rated 8/10), low-grade fever, chest tightness, exertional dyspnea, and a nonproductive cough. Here, RNPC3 is linked to systemic lupus erythematosus.