Apoptotic genes such as CASP8, CASP10, and CFLAR, known for their role in the regulated cell death mechanism (Fig. 2A) and essential in the formation of the embryonic limb, had been previously correlated with microsatellite markers encompassing a deletion within the chromosomal locus 2q31-33 associated with congenital clubfoot. This evidence concerns the gene CASP10 and clubfoot.