Genome-wide association studies (GWAS) have identified a significant link between isolated clubfoot and a specific SNP (rs7969148) situated between the nuclear receptor corepressor 2 (NCOR2) and zinc finger protein 664 (ZNF664) genes on chromosome 12q24.31 42. The gene discussed is ZNF664; the disease is familial clubfoot with or without associated lower limb anomalies.