Pathway enrichment analysis of the 159 key proteins identified from the intersection of NPC-related genes, QZD treatment targets, and high-risk locally advanced NPC-associated genes revealed that the primary intervention pathways of QZD in high-risk locally advanced NPC patients include Apoptosis, PI3K-Akt signaling pathway, Th17 cell differentiation, C-type lectin receptor signaling pathway, Thyroid hormone signaling pathway, EGFR tyrosine kinase inhibitor resistance, Proteoglycans in cancer, Endocrine resistance, Prostate cancer, and Lipid and atherosclerosis (Figure 3a). Here, CLEC4D is linked to atherosclerosis.