TGFB1 and Myocardial fibrosis: Rutin decreases the expression of fibrosis-related genes TGF-β1 and fibronectin, ameliorates histopathological damage in cardiomyocytes, alleviates metabolic acidosis and myocardial fibrosis in diabetic rats, and prevents the progression of DCM (Ganesan et al., 2020).