The protective effects of EGCG were blocked by SIRT1 inhibitors or siRNA, indicating that EGCG alleviates myocardial ischemia/reperfusion (I/R) injury in diabetic rats by activating the SIRT1 signaling pathway and upregulating MnSOD expression (Wu Y. et al., 2017). The gene discussed is SIRT1; the disease is myocardial ischemia.