Luteolin can improve cardiac function in DCM rats, reduce serum levels of MDA, creatine kinase (CK), LDH, and myocardial connective tissue growth factor (CTGF), and increase HO-1, SOD, and phosphorylated Akt levels (Wang et al., 2012). Here, HMOX1 is linked to familial dilated cardiomyopathy.