Although some studies have identified several proteins associated with AD risk through plasma proteomic studies (31), such as GFAP (32), Neurofilament light polypeptide (NEFL), and neurosecretory protein Nerve Growth Factor (VGF) (33), systematic analyses of neuroinflammation-related peripheral plasma between AD patients and healthy individuals are still scarce (19). The gene discussed is NEFL; the disease is Alzheimer disease.