Compared with the HC group, uPA, CX3CL1, CDCP1, Flt3L, SCF and TWEAK proteins were significantly upregulated in AD group, with Area Under the ROC Curve (AUC) values of 0.96 (p = 0.001), 0.90 (p = 0.002), 0.87 (p = 0.005), 0.77 (p = 0.018), 0.89 (p = 0.003) and 0.75 (p = 0.041), respectively, and cutoff values of 10.083 pg./mL, 3.411 pg./mL, 3.391 pg./mL, 9.038 pg./mL, 8.984 pg./mL and 8.998 pg./mL. The gene discussed is TNFSF12; the disease is Alzheimer disease.