Although some studies have identified several proteins associated with AD risk through plasma proteomic studies (31), such as GFAP (32), Neurofilament light polypeptide (NEFL), and neurosecretory protein Nerve Growth Factor (VGF) (33), systematic analyses of neuroinflammation-related peripheral plasma between AD patients and healthy individuals are still scarce (19). Here, VGF is linked to Alzheimer disease.