For example, LINC01123 enhances glycolytic flux by stabilizing c-Myc transcripts; AC020978 binds to pyruvate kinase M2 (PKM2) to simultaneously drive glycolysis and metastasis; and ADPGK-AS1 modulates M2 macrophage polarization via exosomes, thereby reshaping the tumor microenvironment (TME) (21–25). The gene discussed is ADPGK; the disease is neoplasm.