The bZIP transcriptional blocker NFIL3 (nuclear factor interleukin 3-regulated) is overexpressed in different cancers and reduces histone acetylation by combining with neighboring DNA and recruiting histone deacetylase-2 (HDAC2), which prevents the entry of FOXO (Forkhead O) (FOXO1, FOXO3, and FOXO4) transcription factors into TRAIL promoters and into chromatin at the tumor promoter. The gene discussed is HDAC2; the disease is cancer.