CRP and interstitial lung disease: Using the fixed-effects model and IV method for analysis, the pooled results showed that CRP (HR = 1.02, 95%CI: 1.01, 1.02, P < 0.001) was a risk factor for mortality in patients with MDA5+ DM-ILD, whereas CK (HR = 1.00, 95%CI: 1.00, 1.00, P = 0.693) and DLCO% (HR = 1.00, 95%CI: 0.97, 1.04, P = 0.817) had no effect on mortality in MDA5+DM-ILD (Figure 4).