A subsequent study complemented these findings by additionally identifying a carbonyl nucleobase adduct of adenine (M3Ade), MR1-M3Ade loaded tetramers recognized heterogeneous MR1-reactive T-cells in healthy donors and patients with acute myeloid leukemia, and tumor-infiltrating lymphocytes from non-small cell lung adenocarcinoma and hepatocarcinoma ex vivo (18, 74, 75). Here, MR1 is linked to neoplasm.