1. The increase of Th17 cells is closely related to the occurrence of coronary artery lesions, which may lead to coronary artery dilatation or coronary aneurysm formation.2. The decrease of Treg cells may weaken the inhibitory effect on inflammation and aggravate vascular injury. The imbalance of cTfh cell subsets is associated with increased levels of inflammatory markers such as CRP and ESR, which may affect disease severity and treatment response. Here, ESR1 is linked to coronary aneurysm.