These subgroups include the M2b type, activated by immune complexes and TLR ligands to produce pro-inflammatory factors; the M2c type, activated by glucocorticoids or IL-10 to primarily exert anti-inflammatory functions; and the M2d type, also known as TAMs (Tumor-Associated Macrophages), activated by TLR ligands and A2 adenosine receptor agonists, which play key roles in regulating tumor progression, angiogenesis, and metastasis (10). Here, IL10 is linked to neoplasm.