IFNA1 and systemic lupus erythematosus: To uncover the cell-intrinsic mechanisms underlying enhanced IFNα production by STING stimulation, we performed the transcriptomic analysis of monocytes from SLE patients and in vitro IFNα-exposed monocytes from healthy individuals, and found that the transcription factor GATA4 was upregulated in monocytes from SLE patients (Figure 2) (68).