The early ablation of pDCs in BXSB lupus-prone mice prior to disease onset ameliorated lupus nephritis, reduced the tissue expression of IFN-induced genes, and diminished the cascade of IFN-mediated responses, including the reduction of antinuclear antibodies, splenomegaly, and abnormal expansion of T and B cells (51). Here, IFNA1 is linked to Splenomegaly.