STING1 and systemic lupus erythematosus: The cGAS-STING pathway is typically activated in response to DNA derived from pathogenic microbes or viruses, but excess self-DNA, derived from apoptosis-derived membrane vesicles (42), neutrophil extracellular traps (11), and mitochondrial DNA (43) may also contribute to aberrant cGAS-STING activation in SLE.