1. CCL2/CCR2 expression surges in the hippocampus 6 hours post-ischemia, promoting monocyte infiltration.2. M2 microglia secrete anti-inflammatory cytokines (IL-10, TGF-β) and neurotrophic factors (IGF-1) to support CNS repair. The gene discussed is TGFB1; the disease is ischemia.