This oncogenic reprogramming facilitates tumor progression via multiple mechanisms (1): Accelerated glycolysis provides rapid ATP generation and metabolic intermediates for macromolecule biosynthesis (2); Microenvironmental adaptation through hypoxia-inducible factor 1α (HIF-1α)-mediated regulation (3); Promotion of metastatic potential via PI3K/AKT pathway activation. Here, HIF1A is linked to neoplasm.