CD274 and neoplasm: The MNCs mediated PDT treatment in combination with checkpoint blockade significantly suppressed the original and metastasized tumors through three intervention processes ‘trident modality,’ which includes immunosuppressive TEM modification with inhibition of PD-L1 blockade and immunosuppressive cells; increased tumor-infiltrating-lymphocyte (TIL) rates; and steady generation of free radicals in both the hypoxic and normoxic states to directly eradicate the tumor.