A key contributor to APOE’s multifaceted impact on AD risk is the impaired clearance of Aβ and tau conferred by the ε4 allele (Eisenbaum et al., 2024; Hudry et al., 2013; Castellano et al., 2011; Simonovitch et al., 2016; Liu et al., 2017; Deane et al., 2008). The gene discussed is APOE; the disease is Alzheimer disease.