ITGB3 and necrotizing enterocolitis: Integrin-β3 (Itgb3) is a cell-surface receptor on platelets and also a subunit that can bind with Itga2b (αIIb) to form integrin αIIbβ3 (also known as glycoprotein IIb/IIIa or CD61), which is the most abundant integrin on the platelet surface (24), and this higher expression projects platelet activation within 3 h after TNBS (trinitrobenzene sulfonic acid)-induction for murine NEC-like injury (12, 16).