Tissue resected for human NEC showed stronger CD41 immunoreactivity, which was localized on CD14+ monocytes, and not in microthrombi in the gut microvasculature (2.0 ± 0.4 cells/HPF in control tissue vs. 36 ± 0.9 cells/HPF in NEC; P < 0.001). Here, CD14 is linked to necrotizing enterocolitis.