Similarly to human NEC, the murine CD41+ platelets have strong immunoreactivity localized with Ly6C+ monocytes in the intestine (0.56 ± 0.06% of cells in control tissue vs. 77.5 ± 2.52% of cells in murine NEC-like injury; P < 0.001) and blood (5.16 ± 0.33% of cells in control blood vs. 42.01% ± 1.53% of cells in blood of murine NEC-like injury; P < 0.001); and minimal reactivity in spleen (0.08% ± 0.04% of cells in control tissue vs. 12.6% ± 0.42% of cells in murine NEC-like injury; P < 0.001) (Figures 2A,B). Here, ITGA2B is linked to necrotizing enterocolitis.