We recently described (12) that platelet activation was observed with higher expression of αIIb/β3 (glycoprotein [GP] IIb/IIIa), CD31/platelet endothelial cell adhesion molecule (PECAM)-1, and P-selectin (CD62P) at 3 h after TNBS administration, and that platelet activation was an early event during murine NEC-like injury. Here, SELP is linked to necrotizing enterocolitis.