In addition, APX3330 promoted the polarization of M2 macrophages in the ischemic brain of type 1 diabetes mellitus (T1DM) stroke rats, as indicated by a decrease in ED1, an M1 macrophage marker, and increases in CD163, an M2 macrophage marker (Yan et al., 2018). Here, EDA is linked to type 1 diabetes mellitus.