Other medications such as sibutramine, a norepinephrine and serotonin inhibitor, lorcaserin, a serotonin 2C receptor agonist, and beloranib, a methionine aminopeptidase 2 inhibitor, were discontinued due to significant adverse events of thromboembolism and other safety concerns (140). Here, METAP2 is linked to Thromboembolism.