Fifteen of these proteins decreased over age: three were lower in AD models compared to WT already at a young age and continued to decrease further (e.g., SCN2A and PRKCA, Supplemental Figure 1A), while the remaining 12 were increased in AD models in juveniles but decreased in old cohorts >10 months (e.g., SLC1A2 and CPLX2, Supplemental Figure 1B). The gene discussed is SCN2A; the disease is Alzheimer disease.