STX12 and Alzheimer disease: Nine proteins increased with advancing age: 3 were higher in AD models compared to WT from a young age and increased further (e.g., SYT11 and STX12, Supplemental Figure 1C), and 6 were lower in young AD models but increased with age (e.g., DTNBP1 and GABRA3, Supplemental Figure 1D).