In contrast, L. major induces a severe infection in BALB/c mice, a non self‐healing infection, which could not be modulated by HSP65‐producing L. lactis oral treatment since the infection induces a strong Th2‐dominated response, characterised by early elevated production of IL‐4 and IL‐10, which contributes to increased susceptibility and progressive ulceration in BALB/c mice [4, 34, 36, 37, 38, 39, 40]. This evidence concerns the gene HSPD1 and infection.