Two distinct cDC1 activation states are differentially associated with Cxcl9 and Il12b/Ccr7 expression, respectively, each localising to different regions of the tumour, with the Cxcl9+ cDC1s being enriched in the parenchyma while the Il12b+ cDC1s remain located at the edges. The gene discussed is MPPE1; the disease is neoplasm.