Of those, clusters 10 and 8 mapped to the lower and higher “activation bridges” on the UMAP space (Figure 2A), respectively, and expressed higher level of Cd274 and Cd40 (Figures 2B and 3A), suggesting that they might represent endpoint activated cDC1 states in tumours, while clusters 7 and 9 may correspond to transitional states. The gene discussed is CD40; the disease is neoplasm.