On multivariate logistic regression, older age at symptoms onset [adjusted Odds Ratio (aOR) = 1.05, 95% confidence interval (95% CI) = 1.02–1.09], elevated CRP (> 5 mg/L) (aOR = 1.49, 95%CI = 1.04–2.12) and history of atopic dermatitis [aOR = 1.45, 95%CI = 1.96–2.17] were associated with worse QoL (CDLQI > 5) when adjusting for sex. Here, CRP is linked to atopic eczema.