Similarly, in the Drosophila model of GNAO1 encephalopathy, GαoG203R/GαoG203R homozygous mutant flies die at the second larval stage, later than the Gαo−/− null animals that do not survive past the embryonic stage, also suggesting the partial LOF genetics of the mutation (Larasati et al, 2022). Here, GNAO1 is linked to Encephalopathy.