GNAO1 and epilepsy: While the amino acids highlighted in red in Fig. 3 reflect the position that could be mutated in GNAO1-related disorders, dominant variants in this gene can also be found in other diseases/syndromes: [T327R] in severe pediatric speech deficiency (Hildebrand et al, 2020), [R243H] in triple-negative breast cancer (Kan et al, 2010), or [N312S] in diphtheria, tetanus and pertussis vaccination-associated seizures/epilepsy (Negi et al, 2023).