GNA11 and familial hypocalciuric hypercalcemia 2: Missense mutations in GNA11—the gene encoding Gα11, a member of the Gαq subclass—have been associated with the autosomal dominant “Hypocalcemia-2” (HYPOC2; OMIM #615361) and “Hypocalciuric Hypercalcemia type II” (HHC2; OMIM #145981), both disorders of mineral homeostasis (Howles et al, 2023; Mannstadt et al, 2013).