In Alzheimer’s disease (AD), frontotemporal dementia (FTD), and related neurodegenerative brain diseases, Tau aggregates into insoluble amyloid-like fibrils that accumulate in the neuronal cytoplasm as neurofibrillary tangles (NFTs) and correlate with neurotoxicity, neuronal loss, and cognitive decline in these diseases4,5. This evidence concerns the gene MAPT and frontotemporal dementia.