A heatmap (Fig. 3C) depicts alterations in pivotal pathway genes, such as the SLC25A family genes, RAD51, BRCA1, BRCA2, CCNB1, CCNB2, and CDK2, which are substantially correlated with IREB2 expression in BC cell lines (Fig. S1A). The gene discussed is CCNB1; the disease is breast cancer.