Due to these inflammatory effects, dysregulation of serum IgA is implicated in several autoimmune diseases (Breedveld and Van Egmond, 2019), such as inflammatory bowel disease (Lin et al, 2018), rheumatoid arthritis (RA) (Derksen et al, 2022), IgA nephropathy (IgAN) (Suzuki et al, 2009; Coppo and Amore, 2004), and transplant rejection (Arnold et al, 2018). The gene discussed is CD79A; the disease is rheumatoid arthritis.