It has been reported that the mechanism by which ALN improves HRQOL is by improving pain associated with osteoporosis through inhibition of TRPV1 [24], and, furthermore, an RCT showed that ALN has a stronger analgesic effect than calcitonin in women with postmenopausal osteoporosis [25]. The gene discussed is CALCA; the disease is postmenopausal osteoporosis.