SERPINA1 and pulmonary arterial hypertension: Similarly, prime editing has been used to correct mutations in several conditions in mice such as Duchenne muscular dystrophy (Dmd)103, phenylketonuria (Pah)104, retinitis pigmentosa (rpe65)102 and the E342K mutation in the SERPINA1 gene associated with alpha-1 antitrypsin deficiency105.