In line with this observation, CD8 Tem cells were also specified in clonally expanded clonotypes in SLE (Fig. 3e and Supplementary Fig. 8e) with their lower TCR diversity (Fig. 3f) indicating that the selected T cell clones were repeatedly activated, probably in an autoimmune response with augmented cytotoxic activity. Here, CD8A is linked to systemic lupus erythematosus.