In conclusion, this study provides crucial insights into the role of KCTD17 in driving MASH-induced liver fibrosis and elucidates the mechanisms behind the reduced expression of Serpina3k/SERPINA3, as well as the functional consequences in MASH-induced mice and patients with MASH (Supplementary Fig. 8). The gene discussed is KCTD17; the disease is Hepatic fibrosis.