For the composite outcome of cardiovascular death, nonfatal ischemic stroke, nonfatal systemic embolism, or nonfatal myocardial infarction, 5 biomarkers including d-dimer, GDF-15, IL-6, NT-proBNP and hsTropT independently contributed to the model fit (Supplementary Table 1, Fig. 1A). The gene discussed is GDF15; the disease is myocardial infarction.