For heart failure hospitalization, 4 biomarkers - GDF-15, IGFBP-7, NT-proBNP and hsTropT - were significantly associated with the outcome (Supplementary Table 2, Fig. 1B), with NT-proBNP and GDF-15 being among the most important risk predictors (Fig. 2B). This evidence concerns the gene GDF15 and heart failure.