Transgenic models are instrumental to characterize the impact of specific genetic variants on PD pathogenesis, including the overexpression of α-synuclein and Leucine-rich repeat serine/threonine kinase 2 (LRRK2), and the knockout/knockdown of genes like Parkin, Dj-1, PTEN-induced putative kinase 1 (Pink1) [193]. Here, SNCA is linked to Parkinson disease.