HATs also support cancer stemness by enhancing WNT/β-catenin signaling, as demonstrated by EP300, which contributes to CRC stemness and tumorigenicity at least in part by transactivating LGR5 through a mechanism that relies on jade family PHD finger 3 (JADE3).142 EP300 also cooperates with DOT1L to promote the epigenetic derepression of cadherin 1 (CDH1) in breast cancer,127 whereas KAT2A maintains pancreatic CSCs by acetylating H3 on various promoters and enhancers that control WNT/β-catenin signaling.143. The gene discussed is EP300; the disease is breast cancer.