PRDM9 and cancer: In AML, stem-like reacquisition is associated with altered chromatin accessibility and DNA methylation at differentiation-related genes, often as mediated by DNMT3A and TET2.198 Both histone methyltransferases (e.g., PRC2) and demethylases (e.g., KDM1, KDM5, and KDM6 family members) are critical regulators of cancer cell plasticity.