Components of the so-called WRAD complex, a supramolecular entity enabling optimal histone methylation by KMT2s,64 such as WD repeat domain 5 (WDR5) and RB binding protein 5, histone lysine methyltransferase complex subunit (RBBP5), play roles in GSC preservation by stimulating SOX2 and POU5F1 expression.65,66 WDR5 inhibition disrupts tumor propagation in GBM models,65 indicating a key role for WDR5-regulated histone marks in GSC-driven oncogenesis. This evidence concerns the gene POU5F1 and glioblastoma.