In AML, stem-like reacquisition is associated with altered chromatin accessibility and DNA methylation at differentiation-related genes, often as mediated by DNMT3A and TET2.198 Both histone methyltransferases (e.g., PRC2) and demethylases (e.g., KDM1, KDM5, and KDM6 family members) are critical regulators of cancer cell plasticity. Here, TET2 is linked to acute myeloid leukemia.