Among H3K36 demethylases, KDM2A epigenetically activates pluripotency genes in HCC,119 whereas KDM2B upregulation reportedly maintains LSCs and GSCs.120,121 In GBM, KDM2B depletion indeed leads to a decreased CSC compartment along with reduced levels of SOX2 and EZH2.120 Moreover, KDM2B exerts pro-leukemogenic effects by promoting MEIS1-HOXA9 signaling and LSC self-renewal through the repression of CDKN2B (best known as p15) via H3K36me2 demethylation.122. This evidence concerns the gene KDM2B and hepatocellular carcinoma.