EHMT2 activity plays a crucial role in maintaining stemness in CRC88 and melanoma.89 More specifically, while in melanoma, EHMT2 silences DKK1, leading to the derepression of WNT/β-catenin signaling,89 in CRC, it promotes epigenetic reprogramming to promote oncogenesis through WNT/β-catenin signaling activation and EMT induction, as demonstrated by pharmacological EHMT2 inhibitors.88 Here, DKK1 is linked to melanoma.