WNT5A and cancer: Moreover, type I interferon (IFN) released by cancer cells exposed to suboptimal immunogenic chemotherapy activate the histone demethylase KDM1B, triggering a transcriptional rewiring toward a CSC phenotype.205 In addition, type I IFN signaling has been shown to repolarize CAFs into a subset that promotes CSC traits through Wnt family member 5 A (WNT5A) paracrine signaling.206