KMT2A and cancer: Further confirming the role of H3K4 methylation dynamics in cancer stemness, KDM1A (also known as LSD1) has been shown to support CSC function and leukemogenesis downstream of MLL-AF9 translocations by impairing LSC differentiation and apoptosis.73 KDM1A also appears to promote leukemogenesis by (1) enhancing HSC self-renewal upon activation of the MEIS1-HOXA axis74 and (2) interacting with EMT-promoting factors such as snail family transcriptional repressor 1 (SNAI1), redirecting SNAI1 activity from HSC regulation to repression of cell adhesion and oncosuppressor genes.75