SOX2 and cancer: For example, KDM3A enhances cancer stemness by epigenetically activating key genes such as SOX2 and NANOG, at least in the context of ovarian cancer.92 Moreover, KDM3 family members and KDM4C support the tumorigenicity of colorectal CSCs93 and GSCs,94 respectively, via WNT/β-catenin signaling.