PLA2G7 and cancer: For example, Mihee et al proved that darapladib, an inhibitor of lipoprotein-associated phospholipase A2 (LpPLA2), synergistically induces ferroptosis in the presence of GPX4 inhibitors [39]; Ca2+-independent phospholipase A2β (IPLA2β) suppresses ferroptosis by hydrolyzing 15-HpETE-PE, while its genetic or pharmacological inactivation sensitizes cells to ferroptotsis [40]; By resisting ferroptosis, PLA2 family members regulate pathogenesis across multiple diseases: cancer [41, 42], brain injury [43], acute liver injury [44], neurodegenerative disease [45].