NFE2L2 and chronic obstructive pulmonary disease: Resveratrol, a naturally occurring polyphenol found in grapes and other plants, has demonstrated antioxidant and anti-inflammatory properties in various disease models.33, 34 Resveratrol also activates Nrf2 and glutamate-cysteine ligase in human bronchial epithelial cells to reverse CS-induced reduction of GSH levels, which play a role in the treatment of COPD antioxidative effect.35