OSM stimulation of ACMs also potently induced transcripts encoding small proline-rich protein 1A (SPRR1A), which is upregulated in cardiomyocytes by the gp130 family cytokine LIF and promotes cardiomyocyte apoptosis and maladaptive remodeling in response to myocardial infarction [61,62], and SerpinB1, a serine protease inhibitor involved in immune responses [63]. This evidence concerns the gene SPRR1A and myocardial infarction.