Significantly, OSMR deletion protects from dilated cardiomyopathy in muscle LIM protein (MLP) knockout mice [73] which, coupled with data herein demonstrating an explicit requirement for JAK1 in cytokine-induced STAT3 activation, nuclear translocation, and transcriptional reprogramming, suggests JAK1 signaling contributes to maladaptation in certain forms of heart disease. The gene discussed is LPP; the disease is dilated cardiomyopathy.