JAK inhibitors are widely used to treat autoimmune and inflammatory conditions, most notably rheumatoid arthritis [6], as well as to alleviate cytokine storm in critically-ill COVID19 patients [6,76–78], suggesting treatment with JAK1 specific inhibitors may even attenuate STAT3-dependent hypertrophy, cytokine production, and immune cell recruitment that could alleviate excessive inflammation and reduce adverse cardiac remodeling in the stressed adult heart. This evidence concerns the gene STAT3 and rheumatoid arthritis.