PNKP and breast carcinoma: PNKP was one of the top candidates, and further analysis of its expression in the TCGA (The Cancer Genome Atlas) datasets revealed a significant higher expression in breast cancer patients compared to normal women (Fig. 1A), which was associated with poor prognosis in TNBC as demonstrated by the Kaplan–Meier curve (data from METABRIC, Fig. 1B).