In line with our results (Fig. 2M–O, S2D-E), recent studies suggest that STAT3 is upregulated in chemoresistant gastric cancer cells, and it directly binds to the promoter sequences of key negative regulators of ferroptosis, including GPX4, SCL7A11 and FTH1, thereby modulating their expression and protecting cells from ferroptosis [48]. Here, GPX4 is linked to gastric cancer.