To study the combined effect of these mutations on rHA7-Asibi pathogenesis in greater detail, we measured liver viral loads (Fig 6D), liver damage, as determined by increases in the concentration of serum alanine transaminase (ALT) (Fig 6E), and coagulopathy, as determined by measuring prothrombin time (PT) (Fig 6F). This evidence concerns the gene F2 and blood coagulation disease.