TP53 and lung adenocarcinoma: Introduction of gRE, gSS, and g1-g11 had similar effects in the p53-restorable lung adenocarcinoma K-rasG12D/+; p53LSL/LSL; R26-CreERT2 (KPR) cell line, where Tam-mediated p53 restoration activates the p53 response to oncogenic stress (S1C–S1F Fig) [19,21].