Therefore, to clarify which cells in keloids express PIEZO2, we analyzed gene expression at the single‐cell level and found that PIEZO2 was upregulated in vascular endothelial cells (VECs), lymphatic endothelial cells (LECs), and a subgroup of fibroblasts that the extracellular matrix collagen production signaling augmented. The gene discussed is PIEZO2; the disease is keloid.