Mantadakis et al.’s meta-analysis, using a cut-off value of 0.5 to 0.6 ng/ml, demonstrated a pooled diagnostic odds ratio of PCT for culture and DMSA-proven UTI with kidney parenchymal involvement of 14.25 (95% CI [4.7, 42.2]) [26]. The gene discussed is CALCA; the disease is bacterial urinary tract infection.