TNF and allergic asthma: Substantial research has isolated and identified active compounds and revealed multi-levels of beneficial mechanisms, including direct modulating airway smooth muscle contraction (Yang) [84, 85], reduction of Th2 cytokines and increase Tregs (Chang data, Ying), reduced TNF-α (Zhen) and IgE production [86–91] These data will support the further understanding of TCM on allergic asthma and might bring new therapeutic options for allergic asthma.