PINK1 and early-onset autosomal dominant Alzheimer disease: (A, B) Double immunofluorescence staining showing the distribution of PTEN-induced kinase 1 (PINK1) and Aβ (A), and pUb and Aβ (B), within the cingulate gyrus brain region of Alzheimer's disease (AD) patients compared to similar brain regions from age-matched controls.