The Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis showed that pretreatment with NMN downregulated the NF-κB and TNF signaling pathways, cytokine-cytokine receptor interaction, MAPK signaling pathway, and other signaling pathways closely related to bacterial infection in BMDM after hvKP infection (Fig. 3C). The gene discussed is NFKB1; the disease is bacterial infectious disease.