PARP14 and infection: PARP14 is essential for increased IFN-I production in response to infection by coronaviruses that lack ADP-ribosylhydrolase activity – an enzymatic function that reverses host-mediated ADP-ribosylation – or to stimulation with the RNA-mimicking molecule polyinosinic:polycytidylic acid [poly(I:C)] (Grunewald et al., 2019; Parthasarathy and Fehr, 2022).