Specifically, high levels of cytosolic β-NAD+, produced by elevated nicotinamide mononucleotide adenylyltransferase 2 (NMNAT2) expression in ovarian cancer, activate PARP16 on the ER membrane, where PARP16 MARylates ribosomal proteins, including RPL24, impairing polysome assembly and decreasing protein synthesis. Here, NMNAT2 is linked to ovarian carcinoma.