Beyond CRC, PARP14 contributes to tumorigenesis in B-cell lymphoma by inhibiting JNK1 (MAPK8) signaling, thereby preventing apoptosis, and in acute myeloid leukemia by enhancing glycolysis to support cancer cell proliferation (Barbarulo et al., 2013). This evidence concerns the gene MAPK8 and B-cell non-Hodgkin lymphoma.