Characterization of pancreatic ductal adenocarcinoma (PDAC) organoids shows expressions of the surface receptors αvβ6 and EGFR (Figure S6A), both required for internalization of Ad5NULL-A20 and bispecific tumor antigen targeting, respectively, making them a suitable model for demonstrating the potency of OAd5NULL-A20-BICA ex vivo. The gene discussed is EGFR; the disease is pancreatic ductal adenocarcinoma.