T2D: type 2 diabetes; CKD: chronic kidney disease; SGLT-2: sodium-glucose cotransporter-2; GLP-1: glucagon-like peptide-1; UACR: urine albumin-creatinine ratio; HbA1c: glycated hemoglobin; eGFR: estimated glomerular filtration rate. The gene discussed is GLP1R; the disease is type 2 diabetes mellitus.