TLR8 and systemic lupus erythematosus: XCI is heterogenous across different cell types, tissues, and individuals, and about 25% of X- linked genes are suspected to escape XCI, including IRAK1, MECP2, CD40L, TLR7, and TLR8. Interestingly, the inactive X chromosome seems to be predisposed to partial reactivation in lymphocytes in females, resulting in increased expression of X-linked immune genes that augment the risk for development of autoimmune disease such as SLE (Wang et al, 2016).