VGLL3 and Autoimmunity: Substantiating a role for VGLL3 in sex-biased autoimmunity, overexpression of Vgll3 in mouse epidermis—modeling an exaggerated version of human female skin—caused mice to develop skin lesions resembling discoid lupus and features of lupus-like systemic autoimmunity, including B-cell expansion, autoantibody production, immune complex deposition, and end-organ damage (Billi et al, 2019).