Although many factors implicated in lupus pathogenesis were found to be upregulated by VGLL3, specific factors mediating VGLL3’s immunogenic effects have not been definitively identified nor have the factors regulating increased VGLL3 expression in women or sex-specific subcellular localization of VGLL3. The gene discussed is VGLL3; the disease is systemic lupus erythematosus.