VGLL3 and autoimmune disease: Subsequent work has solidified the importance of VGLL3 in inflammation and autoimmunity, with identification of potentially pathogenic roles in fibroblast-like synoviocytes in RA as well as myofibroblasts and endothelial-to-mesenchymal–transitioning cells in SSc—2 autoimmune diseases that also exhibit striking female sex bias (Du et al, 2022; Ma et al, 2024; Pagenkopf and Liang, 2020; Takakura et al, 2021).