It also includes adiponectin (24; 38; 6) and peptide hormones (19; 38; 6), indicating a focus on endocrine networks that modulate insulin sensitivity; the presence of polycystic ovary syndrome (15; 41; 6) and case-control studies (28; 107; 13) points to the analysis of specific clinical contexts in which insulin resistance is pivotal. This evidence concerns the gene INS and Insulin resistance.