⁃ Increased circulating and muscle myonectin levels from endurance treadmill Ex.⁃ Ex’s effects on cardiac damage were diminished under myonectin-deficiency condition.⁃ Myonectin-transgenic mice experienced less severe injury during the ischemia-reperfusion process, with a decrease in apoptotic myocytes in the ischemic myocardium and reduced expression of TNF-a and IL-6 in the ischemic heart. This evidence concerns the gene ERFE and benign neoplasm.