Considering the articles with the most robust evidence and lower risk of bias, as given by the larger and more homogeneous samples, use of controls, high precision in the measurements, adjustments for confounders, and the most complete and detailed reporting of results, it is possible to propose that myonectin tends to be reduced in presence of moderate and severe metabolic disturbances and is inversely related to markers of abdominal obesity, confirming its role in controlling the distribution and expansion of the adipose tissue. Here, ERFE is linked to Abdominal obesity.